Gavreto Food, Alcohol, Supplements and Drug Interactions

GAVRETO

QTY 60 • 100 MG • Capsule • Near 77381

PRALSETINIB (pral SE ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat certain kinds of lung and thyroid cancer.

GAVRETO Lifestyle Interactions

Pralsetinib 100mg, Oral capsule

Grapefruit juice

· Severity: Major

· Notes for Consumers: Avoid grapefruit and grapefruit juice during therapy with Pralsetinib. Side effects may get worse if you drink Grapefruit juice while taking Pralsetinib. Discuss any new or worsening side effects, such as diarrhea, nausea, abdominal pain, and fatigue, with your health care provider.

· Notes for Professionals: Have patients avoid grapefruit or grapefruit juice during pralsetinib treatment due to an increased risk of neratinib-related toxicity. Pralsetinib is a CYP3A and P-glycoprotein (P-gp) substrate and grapefruit juice is a combined P-gp and strong CYP3A inhibitor. Coadministration with another combined P-gp and strong CYP3A inhibitor increased the AUC of pralsetinib by 251%.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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DISCOUNT ONLY - NOT INSURANCE. Discounts are available exclusively through participating pharmacies. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. This program does not make payments directly to pharmacies. Members are required to pay for all prescription purchases. Cannot be used in conjunction with insurance. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. This program is administered by Medical Security Card Company, LLC, Tucson, AZ.

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