FLUVASTATIN ER (Generic for LESCOL XL)

Fluvastatin Sodium 80mg, Oral tablet, extended release

Alcohol

· Severity: Moderate

· Notes for Consumers: In some individuals, Fluvastatin and other "statin" type drugs can decrease the function of the liver. The use of Ethanol or alchohol-containing beverages can increase the risk of side effects to the liver from Fluvastatin. It is best to avoid or limit the use of alcohol-containing beverages during therapy with Fluvastatin. Your prescriber may periodically order certain laboratory blood tests to check the function of the liver while you are receiving Fluvastatin therapy.

· Notes for Professionals: Heavy use of ethanol during fluvastatin therapy can increase the risk of hepatotoxicity. Ethanol intake should be minimized or avoided during therapy with fluvastatin.

Fluvastatin Sodium 80mg, Oral tablet, extended release

Marijuana

· Severity: Moderate

· Notes for Consumers: The effects of marijuana may be increased and side effects may get worse if it is combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.

· Notes for Professionals: The incidence of marijuana associated adverse effects may change following coadministration with fluvastatin. Fluvastatin is an inhibitor of CYP2C9, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with fluvastatin, the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be reduced. These changes in Delta-9-THC and 11-OH-THC plasma concentrations may result in an altered marijuana adverse event profile.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>