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LEVOMILNACIPRAN (le vo mil NA si pran) treats depression. It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It belongs to a group of medications called SNRIs.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medication by mouth with a drink of water. This medication may be taken with or without food. Swallow whole; do not crush, cut, or chew the capsule. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medication more often than directed. Do not stop taking this medication suddenly except upon the advice of your care team. Stopping this medication too quickly may cause serious side effects or your condition may worsen.
Contact your care team about the use of this medication in children. Special care may be needed.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Desvenlafaxine
-Duloxetine
-Linezolid
-MAOIs, such as Marplan, Nardil, and Parnate
-Methylene blue injected into a vein
-Milnacipran
-Venlafaxine
This medication may also interact with the following:
-Alcohol
-Amphetamines
-Aspirin and aspirin-like medications
-Certain medications for mental health conditions
-Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
-Certain medications for sleep
-Certain medications that treat or prevent blood clots, such as warfarin, enoxaparin, and dalteparin
-Clarithromycin
-Diuretics
-Fentanyl
-Furazolidone
-Isoniazid
-Ketoconazole
-Lithium
-Medications for heart rhythm or blood pressure
-NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen
-Procarbazine
-Rasagiline
-Ritonavir
-Sibutramine
-St. John's Wort
-Stimulant medications for ADHD, weight loss, or staying awake
-Tramadol
-Tryptophan
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Tell your care team if your symptoms do not get better or if they get worse. Visit your care team for regular checks on your progress. Because it may take several weeks to see the full effects of this medication, it is important to continue your treatment as prescribed by your care team. Do not stop taking except on your care team's advice. You may develop a severe reaction. Your care team will tell you how much medication to take.
Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your care team.
This medication can cause an increase in blood pressure. Check with your care team for instructions on monitoring your blood pressure while taking this medication.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
Your mouth may get dry. Chewing sugarless gum, sucking hard candy and drinking plenty of water will help. Contact your care team if the problem does not go away or is severe.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
-Heart palpitations—rapid, pounding, or irregular heartbeat
-Increase in blood pressure
-Irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea, which may be signs of serotonin syndrome
-Low sodium level—muscle weakness, fatigue, dizziness, headache, confusion
-Seizures
-Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
-Thoughts of suicide or self-harm, worsening mood, or feelings of depression
-Trouble passing urine
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Change in sex drive or performance
-Constipation
-Excessive sweating
-Nausea
-Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medication after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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