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ENALAPRIL; HYDROCHLOROTHIAZIDE (e NAL a pril; hye droe klor oh THYE a zide) treats high blood pressure. It relaxes your blood vessels and helps your kidneys remove more fluid through the urine, which lowers blood pressure. It is a combination of an ACE inhibitor and diuretic.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Cidofovir
-Dofetilide
-Sacubitril; valsartan
-Tranylcypromine
This medication may also interact with the following:
-Alcohol
-Certain medications for blood pressure, heart disease, irregular heartbeat
-Certain medications for diabetes, such as glipizide or glyburide
-Cholestyramine
-Colestipol
-Diuretics, especially triamterene, spironolactone, or amiloride
-Everolimus
-Lithium
-NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
-Opioids
-Phenobarbital
-Potassium supplements
-Sirolimus
-Sodium aurothiomalate
-Steroid medications, such as prednisone or cortisone
-Temsirolimus
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Check your blood pressure as directed. Know what your blood pressure should be and when to contact your care team.
Do not treat yourself for coughs, colds, or pain while you are using this medication without asking your care team for advice. Some medications may increase your blood pressure.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
Avoid salt substitutes unless you are told otherwise by your care team.
Check with your care team if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medication.
Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects.
Talk to your care team about your risk of skin cancer. You may be more at risk for skin cancer if you take this medication.
This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions or angioedema—skin rash, itching, hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
-Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
-Gout—severe pain, redness, warmth, or swelling in joints, such as the big toe
-Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
-Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
-Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
-Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Change in sex drive or performance
-Cough
-Dizziness
-Headache
-Upset stomach
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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