DUTASTERIDE-TAMSULOSIN (Generic for JALYN)

Dutasteride 0.5mg, Tamsulosin Hydrochloride 0.4mg, Oral capsule

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Grapefruit juice may increase the actions of Tamsulosin and potentially increase its side effects. If the blood pressure drops too low while taking tamsulosin, you may become dizzy or feel faint. To limit this interaction, do not stand or sit up too quickly. You should also limit or avoid grapefruit juice while taking Tamsulosin. Contact your prescriber if you have dizziness that does not go away.

· Notes for Professionals: Hepatic cytochrome P450 enzymes 2D6 and 3A4 are responsible for the extensive metabolism of tamsulosin. Although no clinical studies have been done, tamsulosin should be used with caution with inhibitors of CYP3A4 isoenzymes (e.g., grapefruit juice).

Dutasteride 0.5mg, Tamsulosin Hydrochloride 0.4mg, Oral capsule

Alcohol

· Severity: Moderate

· Notes for Consumers: Use caution when combining tamsulosin with alcohol-containing beverages. Alcohol-containing beverages may increase the effects of tamsulosin, which may lower the blood pressure. If the blood pressure drops too low, you may become dizzy or feel faint. To limit this interaction, avoid or limit alcohol-containing beverages while taking tamsulosin. Do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.

· Notes for Professionals: Use caution when combining tamsulosin with alcohol-containing beverages. Alcohol-containing beverages may increase the effects of tamsulosin, which may lower the blood pressure. Tamsulosin ordinarily does not have much effect on blood pressure and the manufacturer does not make any formal advice on alcohol use, However, published literature suggests that ethanol potentiates antihypertensive effects of alpha blockers, including selective ones like tamsulosin. Some experts advise that the patient to limit alcohol use while using this drug.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>