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DARATUMUMAB; HYALURONIDASE (dar a toom ue mab / hye al ur ON i dase) is a monoclonal antibody. Hyaluronidase is used to improve the effects of daratumumab. It treats certain types of cancer. Some of the cancers treated are multiple myeloma and light-chain amyloidosis.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medicine is for injection under the skin. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Interactions have not been studied.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Your condition will be monitored carefully while you are receiving this medicine.
This medicine can cause serious allergic reactions. To reduce your risk, your health care provider may give you other medicine to take before receiving this one. Be sure to follow the directions from your health care provider.
This medicine can affect the results of blood tests to match your blood type. These changes can last for up to 6 months after the final dose. Your healthcare provider will do blood tests to match your blood type before you start treatment. Tell all of your healthcare providers that you are being treated with this medicine before receiving a blood transfusion.
This medicine can affect the results of some tests used to determine treatment response; extra tests may be needed to evaluate response.
Do not become pregnant while taking this medicine or for 3 months after stopping it. Women should inform their health care provider if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care provider for more information. Do not breast-feed an infant while taking this medicine.
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Keep appointments for follow-up doses as directed. It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching or hives, swelling of the face, lips, or tongue
-Blood clot—chest pain, shortness of breath, pain, swelling or warmth in the leg
-Blurred vision
-Fast, irregular heartbeat
-Infection—fever, chills, cough, sore throat, pain or trouble passing urine
-Injection reactions—dizziness, fast heartbeat, feeling faint or lightheaded, falls, headache, increase in blood pressure, nausea, vomiting, or wheezing or trouble breathing with loud or whistling sounds
-Low red blood cell counts—trouble breathing, feeling faint, lightheaded or falls, unusually weak or tired
-Unusual bleeding or bruising
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Back pain
-Constipation
-Diarrhea
-Pain, tingling, numbness in the hands or feet
-Pain, redness, or irritation at site where injected
-Muscle cramp or pain
-Swelling of the ankles, feet, hands
-Tiredness
-Trouble sleeping
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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This drug is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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