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CYCLOSPORINE (SYE kloe spor een) is used to decrease the immune system's response to a transplanted organ. The medicine is also used for rheumatoid arthritis and psoriasis.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medicine by mouth with a full glass of water. Do not take with grapefruit juice. Swallow the capsules whole. Do not chew or break the capsule. Follow the directions on the prescription label. Take your medicine at regular intervals. Take the capsules at the same time each day and at the same time in relation to meals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 1 year for selected conditions, precautions do apply.
Patients over 65 years old may have a stronger reaction and need a smaller dose.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medicine with any of the following medications:
•bosentan
•cidofovir
•cisapride
•mibefradil
•ranolazine
•red yeast rice, monascus purpureus
•St. John's wort
•tacrolimus
This medicine may also interact with the following medications:
•acyclovir
•allopurinol
•amiloride
•amiodarone
•bromocriptine
•carbamazepine
•certain antibiotics
•cimetidine
•colchicine
•danazol
•digoxin
•female hormones, including contraceptive or birth control pills
•imatinib
•medicines for fungal infections like amphotericin B, fluconazole, itraconazole, terbinafine, and ketoconazole
•medicines for blood pressure like diltiazem, nicardipine, verapamil, enalapril, ramipril, and losartan
•medicines for cholesterol like lovastatin, simvastatin, atorvastatin, and fenofibrate
•medicines for HIV infection like indinavir, nelfinavir, ritonavir, and saquinavir
•medicines that suppress the immune system
•melphalan
•methotrexate
•metoclopramide
•NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
•octreotide
•orlistat
•oxcarbazepine
•phenobarbital
•phenytoin
•ranitidine
•sirolimus
•spironolactone
•steroid medicines like prednisone or cortisone
•sulfinpyrazone
•ticlopidine
•triamterene
•vaccines
•voriconazole
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your doctor or health care professional for regular checks on your progress. You will have regular blood checks. Do not change the brand of medicine unless directed by your doctor or health care professional.
If you get a cold or other infection while receiving this medicine, call your doctor or health care professional. Do not treat yourself. The medicine may decrease your body's ability to fight infections.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
The medicine can cause unusual growth of gum tissue and can make your gums bleed. Practice good oral hygiene, and be careful when brushing and flossing your teeth. See your dentist regularly.
Some products may contain alcohol. Ask your pharmacist or healthcare provider if this medicine contains alcohol. Be sure to tell all healthcare providers you are taking this medicine. Certain medicines, like metronidazole and disulfiram, can cause an unpleasant reaction when taken with alcohol. The reaction includes flushing, headache, nausea, vomiting, sweating, and increased thirst. The reaction can last from 30 minutes to several hours.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Call your doctor or health care professional if you miss more than one dose or if you miss doses on a regular basis.
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Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•changes in vision
•high blood pressure
•increased urge to urinate or frequent urination
•numbness or tingling in the hands and feet
•seizures
•severe stomach pain
•vomiting
•yellowing of the skin or the whites of the eyes
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•bleeding or tender gums, overgrowth of gum tissue
•diarrhea
•excessive hair growth on the face or body
•nausea
•tremors
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children.
Store Neoral between 20 and 25 degrees C (68 and 77 degrees F).
Store Gengraf between 15 and 30 degrees C (59 and 86 degrees F).
Keep the medicine in the original packaging. Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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