COXANTO Lifestyle Interactions

  • Thiotepa 15mg, Powder for solution for injection

    • Interaction: Grapefruit juice
    • Severity: Major
    • Notes for Consumers: Do not take thiotepa with grapefruit or grapefruit juice. Taking thiotepa and grapefruit juice together may cause Thiotepa to not work as well for you.
    • Notes for Professionals: Avoid the concomitant use of thiotepa and grapefruit juice; reduced metabolism to the active thiotepa metabolite may result in decreased thiotepa efficacy. In vitro, thiotepa is metabolized via CYP3A4 to the active metabolite, TEPA; grapefruit juice is a strong CYP3A4 inhibitor.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.