CLOFARABINE (Generic for CLOLAR)

CLOFARABINE (kloe FAR a been) treats acute leukemia. It works by slowing down the growth of cancer cells.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

This medication is injected into a vein. It is given by your care team in a hospital or clinic setting.
Talk to your care team about the use of this medication in children. While this drug may be prescribed for children as young as 1 year of age for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

-Acetaminophen
-Amiodarone
-Aspirin and aspirin-like medicines
-Certain medications for blood pressure, heart disease, irregular heart beat
-Certain medications for cholesterol, such as atorvastatin, simvastatin
-Certain medications for fungal infections, such as amphotericin B, fluconazole, and ketoconazole
-Certain medications for infection, such as acyclovir, adefovir, amoxicillin, bacitracin, cidofovir, erythromycin, foscarnet, ganciclovir, gentamicin, minocycline, pentamidine, sulfamethoxazole/trimethoprim, telithromycin, tetracycline, vancomycin
-Certain medications for seizures, such as carbamazepine, phenytoin, valproic acid/divalproex sodium
-Cisplatin
-Cyclosporine
-Diuretics
-Isoniazid
-Lomitapide mesylate
-Methotrexate
-Methyldopa
-NSAIDs, medicines for pain and inflammation, such as ibuprofen or naproxen
-Pamidronate
-Rifampin
-Zoledronic acid

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Your condition will be monitored carefully while you are receiving this medication.
You may need blood work done while you are taking this medication.
This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.
Talk to your care team if you or your partner wish to become pregnant or think either of you might be pregnant. This medication can cause serious birth defects if taken during pregnancy or for 6 months after stopping it. Do not breast-feed while taking this medication or for 2 weeks after stopping it.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
-Capillary leak syndrome—stomach or muscle pain, unusual weakness or fatigue, feeling faint or lightheaded, decrease in the amount of urine, swelling of the ankles, hands, or feet, trouble breathing
-Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
-Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stools, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
-Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
-Redness, blistering, peeling, or loosening of the skin, including inside the mouth
-Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
-Tumor lysis syndrome (TLS)—nausea, vomiting, diarrhea, decrease in the amount of urine, dark urine, unusual weakness or fatigue, confusion, muscle pain or cramps, fast or irregular heartbeat, joint pain
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Headache
-Loss of appetite
-Nausea
-Pain in the hands or feet
-Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.