BUPIVACAINE HCL-EPINEPHRINE (Generic for MARCAINE-EPINEPHRINE)

Bupivacaine Hydrochloride 0.25%, Epinephrine Bitartrate 1:200,000, Solution for injection

Marijuana

· Severity: Major

· Notes for Consumers: Combining marijuana with this medicine may increase blood pressure or heart rate. It can also increase nervousness or troubles with sleep. Contact your health care provider right away if you develop a fast or irregular heartbeat, a severe headache, or other new or unusual side effects.

· Notes for Professionals: Avoid concurrent use of marijuana and epinephrine as use may result in adverse cardiovascular effects, such as tachycardia and cardiac arrhythmias. Marijuana is known to produce significant increases in heart rate and cardiac output lasting for 2 to 3 hours. Further, rare case reports of myocardial infarction and cardiac arrhythmias have been associated with marijuana use. Epinephrine has also been reported to produce a wide range of cardiovascular effects including cardiac arrhythmias, palpitations, hypertension, premature ventricular contractions (PVCs), and sinus tachycardia.

Bupivacaine Hydrochloride 0.25%, Epinephrine Bitartrate 1:200,000, Solution for injection

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Limit excessive Caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Epinephrine and avoid medicines containing additional Caffeine whenever possible. Taking a high amount of Caffeine with Epinephrine can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, or other side effects.

· Notes for Professionals: Caffeine is a CNS-stimulant and such actions are expected to be additive when coadministered with other CNS stimulants or psychostimulants.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>