AYVAKIT

Avapritinib 100mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Avapritinib with Grapefruit or Grapefruit Juice. Side effects from Avapritinib including swelling, nausea, vomiting, tiredness, problems thinking, risk of bleeding, loss of appetite, and signs and symptoms of liver injury like dark yellow or brown urine, light-colored stools, right upper belly pain, and yellowing of the eyes or skin.

· Notes for Professionals: Advise patients to avoid grapefruit or grapefruit juice during avapritinib treatment due to the increased risk of avapritinib-related adverse reactions. Avapritinib is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor is predicted to increase the AUC of avapritinib by 600% at steady-state.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>