ANGELIQ

DROSPIRENONE; ESTRADIOL (dro SPY re nown; es tra DYE ole) reduces the number and severity of hot flashes due to menopause. It may also help relieve the symptoms of menopause, such as vaginal irritation, dryness, or pain during sex. It works by increasing levels of the hormones estrogen and progestin in your body. It is a combination of the hormones estrogen and progestin.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Take this medication at the same time each day. Do not take your medication more often than directed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

Do not take this medication with any of the following:
-Amprenavir, fosamprenavir
-Aromatase inhibitors, such as aminoglutethimide, anastrozole, exemestane, letrozole, testolactone
-Atazanavir; cobicistat
-Bosentan
-Metyrapone
This medication may also interact with the following:
-Acetaminophen
-Antiviral medications for HIV or AIDS
-Aprepitant
-Barbiturates
-Certain antibiotics, such as clarithromycin, erythromycin, rifampin, rifabutin, rifapentine, and possibly penicillins or tetracyclines
-Certain diuretics, such as amiloride, spironolactone, triamterene
-Certain medications for fungal infections, such as griseofulvin, ketoconazole, itraconazole
-Certain medications for high blood pressure or heart conditions, such as ACE-inhibitors, Angiotensin-II receptor blockers, eplerenone
-Certain medications for seizures, such as carbamazepine, oxcarbazepine, phenobarbital, phenytoin
-Cholestyramine
-Cobicistat
-Corticosteroid, such as hydrocortisone and prednisolone
-Cyclosporine
-Dantrolene
-Felbamate
-Grapefruit juice
-Heparin
-Lamotrigine
-Medications for diabetes, including pioglitazone
-Modafinil
-NSAIDs
-Potassium supplements
-Pyrimethamine
-Raloxifene
-St. John's wort
-Sulfasalazine
-Tamoxifen
-Topiramate
-Thyroid hormones
-Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your care team for regular checks on your progress. You should have a complete check-up every 6 months. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your care team, and follow their guidelines.
This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medication at once and contact your care team.
Talk to your care team if you use tobacco products. Changes to your treatment plan may be needed. Tobacco increases the risk of getting a blood clot or having a stroke while you are taking this medication. This risk is higher if you are over the age of 35.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your care team.
If you are going to have elective surgery, you may need to stop taking this medication beforehand. Consult your care team for advice prior to scheduling the surgery.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Side effects that you should report to your care team as soon as possible:
-Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, lips, tongue, arms, or legs, trouble swallowing or breathing
-Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
-Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
-Change in vision such as blurry vision, seeing halos around lights, vision loss
-Gallbladder problems—severe stomach pain, nausea, vomiting, fever
-Heart attack
-High potassium level—muscle weakness, fast or irregular heartbeat
-Increase in blood pressure
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
-Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Breast pain or tenderness
-Confusion
-Dark patches of skin on the face or other sun-exposed areas
-Headaches
-Irregular menstrual cycles or spotting
-Mood swings
-Stomach pain
-Weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children and pets.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.